B6.Cg-Foxp3tm1.1Mal/Orl
| Status | Available to order |
| EMMA ID | EM:01945 |
| International strain name | B6.Cg-Foxp3tm1.1Mal/Orl |
| Alternative name | B6-FoxP3tm1mal, FoxP3 EGFP |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Foxp3.1tm1Mal, |
| Gene/Transgene symbol | Foxp3 |
Information from provider
| Provider | Bernard Malissen |
| Provider affiliation | Centre D |
| Genetic information | An IRES-EGFP cassette was introduced in the 3'-UTR region of Foxp3 gene, exon11. The autodeleter neomycin-cre recombinase cassette was used. |
| Phenotypic information | EGFP labels all regulatory T cells. Very specific labeling, all EGFP+ cells are FOXP3+. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome / Orphanet_37042
Literature references
- Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.;Wang Ying, Kissenpfennig Adrien, Mingueneau Michael, Richelme Sylvie, Perrin Pierre, Chevrier Stéphane, Genton Céline, Lucas Bruno, DiSanto James P, Acha-Orbea Hans, Malissen Bernard, Malissen Marie, ;2008;Journal of immunology (Baltimore, Md. : 1950);180;1565-75; 18209052
- Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells.;Lalfer Mélanie, Chappert Pascal, Carpentier Maxime, Urbain Dominique, Davoust Jean M, Gross David-Alexandre, ;2019;Frontiers in immunology;10;521; 30941146