- microcephaly / MGI
- decreased brain size / MGI
- abnormal cerebral cortex morphology / MGI
- decreased body size / MGI
- premature death / MGI
- small olfactory bulb / MGI
- increased neuron apoptosis / MGI
- abnormal forebrain development / MGI
- loss of cortex neurons / MGI
- abnormal mitosis / MGI
- abnormal embryonic/fetal subventricular zone morphology / MGI
- thin cerebral cortex / MGI
- small hippocampus / MGI
- abnormal mitotic spindle morphology / MGI
- abnormal neuron proliferation / MGI
- enlarged brain ventricles / MGI
- kyphosis / MGI
- decreased leukocyte cell number / MGI
- abnormal erythropoiesis / MGI
- macrocytosis / MGI
- abnormal spermatogenesis / MGI
- anemia / MGI
- reduced fertility / MGI
- postnatal lethality / MGI
- decreased germ cell number / MGI
- abnormal erythrocyte morphology / MGI
- anisocytosis / MGI
- macrocytic anemia / MGI
- premature hair loss / MGI
- decreased oocyte number / MGI
- reticulocytopenia / MGI
- eye opacity / MGI
- increased ovary adenoma incidence / MGI
- decreased erythrocyte cell number / MGI
STOCK Cdk5rap2an/Ieg
Status | Available to order |
EMMA ID | EM:00197 |
International strain name | STOCK Cdk5rap2an/Ieg |
Alternative name | Hertwig`s anemia, an |
Strain type | Induced Mutant Strains : Radiation-induced |
Allele/Transgene symbol | Cdk5rap2an, |
Gene/Transgene symbol | Cdk5rap2 |
Information from provider
Provider | Dietmar Schlote |
Provider affiliation | Martin-Luther University, Halle/Wittenberg |
Phenotypic information | Normochromic macrocytic type of anemia, lethal within the first post-natal weeks. |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive primary microcephaly / Orphanet_2512
MGI phenotypes (allele matching)
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