MGI phenotypes (allele matching)
B6.Cg-Tolliptm1Kbns/Cnrm
| Status | Available to order |
| EMMA ID | EM:01970 |
| International strain name | B6.Cg-Tolliptm1Kbns/Cnrm |
| Alternative name | C57BL/6-TgH(Tollip)23Siec |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tolliptm1Kbns, |
| Gene/Transgene symbol | Tollip |
Information from provider
| Provider | Jurg TSCHOPP |
| Provider affiliation | Departement de Biochimie-Université de Lausanne |
| Genetic information | The targeting vector was generated by replacing a 11.5 Kb genomic fragment, encoding the N-terminal region of Tollip, with a neomycin cassette. |
| Phenotypic information | Defective inflammatory responses such as reduced cytokines production. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.;Didierlaurent Arnaud, Brissoni Brian, Velin Dominique, Aebi Natalia, Tardivel Aubry, Käslin Edgar, Sirard Jean Claude, Angelov Georgi, Tschopp Jürg, Burns Kimberly, ;2006;Molecular and cellular biology;26;735-42; 16428431