MGI phenotypes (allele matching)
B6.Cg-Tolliptm1Kbns/Cnrm
| Status | Available to order |
| EMMA ID | EM:01970 |
| Citation information | RRID:IMSR_EM:01970 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tolliptm1Kbns/Cnrm |
| Alternative name | C57BL/6-TgH(Tollip)23Siec |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tolliptm1Kbns |
| Gene/Transgene symbol | Tollip |
Information from provider
| Provider | Jurg TSCHOPP |
| Provider affiliation | Departement de Biochimie-Université de Lausanne |
| Genetic information | The targeting vector was generated by replacing a 11.5 Kb genomic fragment, encoding the N-terminal region of Tollip, with a neomycin cassette. |
| Phenotypic information | Defective inflammatory responses such as reduced cytokines production. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.;Didierlaurent Arnaud, Brissoni Brian, Velin Dominique, Aebi Natalia, Tardivel Aubry, Käslin Edgar, Sirard Jean Claude, Angelov Georgi, Tschopp Jürg, Burns Kimberly, ;2006;Molecular and cellular biology;26;735-42; 16428431
- Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice.;Liu Yi, Jiang Xiao-Li, Liu Yu, Jiang Ding-Sheng, Zhang Yan, Zhang Rui, Chen Yingjie, Yang Qinglin, Zhang Xiao-Dong, Fan Guo-Chang, Li Hongliang, ;2014;Cardiovascular research;101;87-96; 24285748
- Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia-Reperfusion Injury in Mice.;Yan Zhen-Zhen, Huang Yong-Ping, Wang Xin, Wang Hai-Ping, Ren Fei, Tian Rui-Feng, Cheng Xu, Cai Jie, Zhang Yan, Zhu Xue-Yong, She Zhi-Gang, Zhang Xiao-Jing, Huang Zan, Li Hongliang, ;2019;Hepatology (Baltimore, Md.);70;1750-1769; 31077413
- Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis.;Wan Nian, Liu Xiaoxiong, Zhang Xiao-Jing, Zhao Yichao, Hu Gangying, Wan Fengwei, Zhang Rui, Zhu Xueyong, Xia Hao, Li Hongliang, ;2015;British journal of pharmacology;172;3383-96; 25765712