B6Rcc.Cg-Ptprca/Cnrm
| Status | Available to order |
| EMMA ID | EM:01998 |
| International strain name | B6Rcc.Cg-Ptprca/Cnrm |
| Alternative name | C57 BL/6RCC Ly5.1 |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Ptprca, |
| Gene/Transgene symbol | Ptprc |
Information from provider
| Provider | Ursula Günthert |
| Provider affiliation | Institut für Pathologie, University of Basel |
| Genetic information | Ptprca (or CD45.1 or Ly5.1): spontaneous mutation in the Ptprc gene, distinguishing it from CD45.2 congenic strains. |
| Phenotypic information | Ptprca (or CD45.1 or Ly5.1): used as congenic marker for transplant studies. Used in combination with B6 Cd44v10-/- Ly5.2; B6 Cd44v10-/- Ly5.1; B6 Cd44WT Ly5.2. |
| Breeding history | 10 generations backcrossed onto C57BL/6Rcc; currently bred as C57BL/6Rcc Ly5.1 |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- T-B+ severe combined immunodeficiency due to CD45 deficiency / Orphanet_169157
Literature references
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).;Wittig B M, Johansson B, Zöller M, Schwärzler C, Günthert U, ;2000;The Journal of experimental medicine;191;2053-64; 10859330
- Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.;Morse H C, ;1992;Journal of immunology (Baltimore, Md. : 1950);149;3129-34; 1431091