- abnormal mammary gland development / MGI
- abnormal ovarian folliculogenesis / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina epithelium morphology / MGI
- decreased body weight / MGI
- increased incidence of induced tumors / MGI
- ovary atrophy / MGI
- uterus atrophy / MGI
- reproductive system phenotype / MGI
- adrenal gland hyperplasia / MGI
- absent nipple / MGI
- increased mammary gland tumor incidence / MGI
- mammary gland hyperplasia / MGI
- anemia / MGI
- premature death / MGI
- increased intestinal adenoma incidence / MGI
- increased intestinal adenocarcinoma incidence / MGI
- abnormal pregnancy / MGI
- extended life span / MGI
- aneuploidy / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased intestinal adenoma incidence / MGI
- decreased hematocrit / MGI
- hyperlipidemia / MGI
- melena / MGI
- rectal prolapse / MGI
- abnormal intestinal mucosa morphology / MGI
- increased mammary adenocarcinoma incidence / MGI
- intestinal obstruction / MGI
- abnormal intestinal goblet cell morphology / MGI
- abnormal large intestine crypts of Lieberkuhn morphology / MGI
- intestine polyps / MGI
- abnormal enterocyte proliferation / MGI
- decreased T cell number / MGI
- decreased NK cell number / MGI
- decreased splenocyte number / MGI
- neoplasm / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- postnatal growth retardation / MGI
- increased colonic adenoma incidence / MGI
- hepatic steatosis / MGI
- decreased macrophage cell number / MGI
- increased prostaglandin level / MGI
- abnormal embryo development / MGI
- abnormal embryo size / MGI
- abnormal egg cylinder morphology / MGI
- abnormal cell physiology / MGI
- embryonic lethality, complete penetrance / MGI
- decreased embryo size / MGI
- embryonic lethality between implantation and placentation / MGI
- absent mandible / MGI
- abnormal brain development / MGI
- acrania / MGI
- perinatal lethality, complete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- absent midbrain / MGI
- absent forebrain / MGI
- abnormal liver morphology / MGI
- decreased acute inflammation / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased bone mineral density / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal inflammatory response / MGI
- decreased susceptibility to viral infection / MGI
- dilated renal tubules / MGI
- decreased heart weight / MGI
- delayed wound healing / MGI
- nervous system phenotype / MGI
- abnormal physiological neovascularization / MGI
- renal tubular necrosis / MGI
- increased osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- decreased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- abnormal response to infection / MGI
- decreased cardiac muscle contractility / MGI
- increased susceptibility to injury / MGI
- skeleton phenotype / MGI
- hyporesponsive to tactile stimuli / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- increased interleukin-10 secretion / MGI
- decreased interleukin-12 secretion / MGI
- increased interleukin-4 secretion / MGI
- decreased sensitivity to induced cell death / MGI
- increased trabecular bone thickness / MGI
- mortality/aging / MGI
- decreased fibroblast chemotaxis / MGI
- increased bone marrow cell number / MGI
- abnormal blood cell morphology/development / MGI
- abnormal bone mineralization / MGI
- increased hematopoietic stem cell number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
B6Rcc.Cg-Spp1tm1Rit ApcMin/Cnrm
Status | Available to order |
EMMA ID | EM:02002 |
International strain name | B6Rcc.Cg-Spp1tm1Rit ApcMin/Cnrm |
Alternative name | C57 BL/6RCC Min/+ OPN-/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Spp1tm1Rit, |
Gene/Transgene symbol | Spp1 |
Information from provider
Provider | Ursula Günthert |
Provider affiliation | Institut für Pathologie, University of Basel |
Genetic information | Ethylnitrosurea induced mutation. A transversion point mutation in the Apc (adenomatosis polyposis coli) gene that alters nucleotide 2549 from a T to an A and converts codon 850 from one encoding a leucine to a stop codon, generating the mutant allele ApcMin (adenomatosis polyposis coli; multiple intestinal neoplasia). The neomycin cassette from pMC1neo was inserted into the EagI site in exon 6 of the Spp1 (secreted phosphoprotein 1; formerly: Opn, osteopontin) gene (a 4.8 kb fragment from 129 mice), that had been cloned into pBluescript (Rittling et al., 1998). |
Phenotypic information | Min/+: development of early stages of colon carcinoma: polyps. Opn (Spp1) -/-: influence on colon carcinoma not known. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Desmoid tumor / Orphanet_873
- Cenani-Lenz syndrome / Orphanet_3258
- Turcot syndrome with polyposis / Orphanet_99818
- Gastric adenocarcinoma and proximal polyposis of the stomach / Orphanet_314022
- Gardner syndrome / Orphanet_79665
- APC-related attenuated familial adenomatous polyposis / Orphanet_247806
MGI phenotypes (allele matching)
Literature references
- A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722
- Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro.;Rittling S R, Matsumoto H N, McKee M D, Nanci A, An X R, Novick K E, Kowalski A J, Noda M, Denhardt D T, ;1998;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;13;1101-11; 9661074
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