IMPC phenotypes (gene matching)
129-Trraptm1.1Zqw/Orl
| Status | Available to order |
| EMMA ID | EM:02013 |
| Citation information | RRID:IMSR_EM:02013 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Trraptm1.1Zqw/Orl |
| Alternative name | Trrap+/delta |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trraptm1.1Zqw |
| Gene/Transgene symbol | Trrap |
Information from provider
| Provider | Zdenko Herceg |
| Provider affiliation | International Agency for Research on Cancer (IARC) |
| Genetic information | An exon was deleted via in vitro Cre mediated recombination of an upstream single loxP site and the 3' loxP site of a downstream floxed neo cassette. |
| Phenotypic information | Homozygous embryos die at peri-implantation stage. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal cornea morphology / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- increased mean corpuscular volume / MGI
- absent inner cell mass / MGI
- abnormal trophoblast layer morphology / MGI
- abnormal trophoblast giant cell morphology / MGI
- increased circulating magnesium level / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality before implantation, complete penetrance / MGI
Literature references
- Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.;Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, Jackson S, Wang Z Q, ;2001;Nature genetics;29;206-11; 11544477