129-Trraptm1.1Zqw/Orl

Status

Available to order

EMMA IDEM:02013
International strain name129-Trraptm1.1Zqw/Orl
Alternative nameTrrap+/delta
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTrraptm1.1Zqw,
Gene/Transgene symbolTrrap

Information from provider

ProviderZdenko Herceg
Provider affiliationInternational Agency for Research on Cancer (IARC)
Genetic informationAn exon was deleted via in vitro Cre mediated recombination of an upstream single loxP site and the 3' loxP site of a downstream floxed neo cassette.
Phenotypic informationHomozygous embryos die at peri-implantation stage.
References
  • Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.;Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, Jackson S, Wang Z Q, ;2001;Nature genetics;29;206-11; 11544477

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
MGI phenotypes (allele matching)
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • absent inner cell mass / MGI
  • abnormal trophoblast layer morphology / MGI
  • abnormal trophoblast giant cell morphology / MGI
  • embryonic lethality before implantation, complete penetrance / MGI

Literature references

  • Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.;Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, Jackson S, Wang Z Q, ;2001;Nature genetics;29;206-11; 11544477

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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