B6.Cg-Tg(Prnp/IGHG1)588Aag/Cnrm
| Status | Available to order |
| EMMA ID | EM:02031 |
| International strain name | B6.Cg-Tg(Prnp/IGHG1)588Aag/Cnrm |
| Alternative name | PrPFcSTOP588 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp/IGHG1)588Aag, |
| Gene/Transgene symbol | Tg(Prnp/IGHG1)588Aag |
Information from provider
| Provider | Adriano Aguzzi |
| Provider affiliation | Univ.Hosp.Zurich/Inst.Neuropathology |
| Genetic information | The pHGStopPrP-Fc construct was used for nuclear injection, with a loxP-flanked transcriptional stop cassette (pBS302, Invitrogen) inserted upstream of the PrP-Fc ORF. The generated Tg588 line can be bred with a cre recombinase-expressing line to enable ubiquitous or tissue-specific expression of PrP-Fc. |
| Phenotypic information | None. |
| Breeding history | A founder of the Tg588 line was bred with a C57BL/6 mouse. Breeding of transgene-hemizygous animals (with wild-type Prnp +/+ genotype) with C57BL/6 mice continued for more than 5 generations. The Tg588 transgene-positive mice are viable and without any defect also on the Prnp -/- (129/Sv x C57BL/6) background. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease.;Meier Philipp, Genoud Nicolas, Prinz Marco, Maissen Manuela, Rülicke Thomas, Zurbriggen Andreas, Raeber Alex J, Aguzzi Adriano, ;2003;Cell;113;49-60; 12679034