MGI phenotypes (allele matching)
B6.129P2-Igh-Jtm1Cgn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02078 |
| International strain name | B6.129P2-Igh-Jtm1Cgn/Cnrm |
| Alternative name | B6-Igh-JHT |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Igh-Jtm1Cgn, |
| Gene/Transgene symbol | Igh-J |
Information from provider
| Provider | Klaus Rajeswky |
| Provider affiliation | Harvard Medical School |
| Genetic information | Deletion of JH1, 2, 3 and 4 elements including the DQ52 gene segment and the heavy chain enhancer. |
| Phenotypic information | B cell deficiency. Mice are immunosuppressed, they show an impaired pathogen defense. |
| Breeding history | Backcrossing to C57BL/6 (N=10); inbred by intercross of homozygous pups. Under good hygienic conditions normal breeding performance. In general fewer females are born. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.;Gu H, Zou Y R, Rajewsky K, ;1993;Cell;73;1155-64; 8513499