B6.129P2-Tg(Dyrk1a)189N3Yah/JmdOrl
| Status | Available to order |
| EMMA ID | EM:02119 |
| International strain name | B6.129P2-Tg(Dyrk1a)189N3Yah/JmdOrl |
| Alternative name | 189-N3 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Dyrk1a)189N3Yah |
| Gene/Transgene symbol | Tg(Dyrk1a)189N3Yah |
Information from provider
| Provider | Jean Maurice Delabar |
| Provider affiliation | EA3508- IFR117- Univ Paris7 |
| Genetic information | Electroporation of a 200kb BAC clone containing the full murine Dyrk1a gene in ES cells (collaboration with Dr Y Herault). |
| Phenotypic information | Brain defect: volume increase particularly of the ventral part of the brain. |
| Breeding history | Backcrossed to C57BL/6, N=5 |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.;Branchi Igor, Bichler Zoë, Minghetti Luisa, Delabar Jean Maurice, Malchiodi-Albedi Fiorella, Gonzalez Marie-Claude, Chettouh Zoubidda, Nicolini Alessia, Chabert Caroline, Smith Desmond J, Rubin Edward M, Migliore-Samour Danièle, Alleva Enrico, ;2004;Journal of neuropathology and experimental neurology;63;429-40; 15198122
- Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.;Duchon Arnaud, Del Mar Muniz Moreno Maria, Martin Lorenzo Sandra, Silva de Souza Marcia Priscilla, Chevalier Claire, Nalesso Valérie, Meziane Hamid, Loureiro de Sousa Paulo, Noblet Vincent, Armspach Jean-Paul, Brault Veronique, Herault Yann, ;2021;Human molecular genetics;30;771-788; 33693642