B6.129P2-Nr3c1tm3Gsc/Ieg
Status | Available to order |
EMMA ID | EM:02123 |
International strain name | B6.129P2-Nr3c1tm3Gsc/Ieg |
Alternative name | GRdim |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Nr3c1tm3Gsc, |
Gene/Transgene symbol | Nr3c1 |
Information from provider
Provider | Günther Schütz |
Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
Genetic information | Point mutation (A458T) in the glucocorticoid receptor impairing dimerization and therefore Gre-dependent transactivation. |
Phenotypic information | None. |
Breeding history | Backcrossed in C57BL/6 for >10 generations. |
References |
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Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Generalized glucocorticoid resistance syndrome / Orphanet_786
MGI phenotypes (allele matching)
Literature references
- DNA binding of the glucocorticoid receptor is not essential for survival.;Reichardt H M, Kaestner K H, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schütz G, ;1998;Cell;93;531-41; 9604929
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