B6.129P2-Nr3c1tm2Gsc/Ieg
| Status | Available to order |
| EMMA ID | EM:02124 |
| International strain name | B6.129P2-Nr3c1tm2Gsc/Ieg |
| Alternative name | GRflox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Nr3c1tm2Gsc, |
| Gene/Transgene symbol | Nr3c1 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | Exon3 of the glucocorticoid receptor is flanked by loxP sites allowing Cre-dependent excision. |
| Phenotypic information | None. |
| Breeding history | Backcrossed in C57BL/6 for >10 generations. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Generalized glucocorticoid resistance syndrome / Orphanet_786
Literature references
- Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety.;Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban P C, Bock R, Klein R, Schütz G, ;1999;Nature genetics;23;99-103; 10471508
- Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.;Ince Louise M, Zhang Zhenguang, Beesley Stephen, Vonslow Ryan M, Saer Ben R, Matthews Laura C, Begley Nicola, Gibbs Julie E, Ray David W, Loudon Andrew S I, ;2019;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;33;126-139; 29965797
- Glucocorticoid receptor is required for foetal heart maturation.;Rog-Zielinska Eva A, Thomson Adrian, Kenyon Christopher J, Brownstein David G, Moran Carmel M, Szumska Dorota, Michailidou Zoi, Richardson Jennifer, Owen Elizabeth, Watt Alistair, Morrison Harris, Forrester Lesley M, Bhattacharya Shoumo, Holmes Megan C, Chapman Karen E, ;2013;Human molecular genetics;22;3269-82; 23595884
- Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.;Agnew E J, Garcia-Burgos A, Richardson R V, Manos H, Thomson A J W, Sooy K, Just G, Homer N Z M, Moran C M, Brunton P J, Gray G A, Chapman K E, ;2019;The Journal of endocrinology;241;279-292; 31013474
- Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis.;Richardson Rachel V, Batchen Emma J, Thomson Adrian J W, Darroch Rowan, Pan Xinlu, Rog-Zielinska Eva A, Wyrzykowska Wiktoria, Scullion Kathleen, Al-Dujaili Emad A S, Diaz Mary E, Moran Carmel M, Kenyon Christopher J, Gray Gillian A, Chapman Karen E, ;2017;The Journal of endocrinology;232;437-450; 28057868
- Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α.;Rog-Zielinska E A, Craig M-A, Manning J R, Richardson R V, Gowans G J, Dunbar D R, Gharbi K, Kenyon C J, Holmes M C, Hardie D G, Smith G L, Chapman K E, ;2015;Cell death and differentiation;22;1106-16; 25361084