MGI phenotypes (gene matching)
B6.129-Atf1tm1Gsc/Ieg
| Status | Available to order |
| EMMA ID | EM:02133 |
| Citation information | RRID:IMSR_EM:02133 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Atf1tm1Gsc/Ieg |
| Alternative name | ATF-1 -/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Atf1tm1Gsc |
| Gene/Transgene symbol | Atf1 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | Disruption of the Atf1 gene by homologous recombination of a construct containing lacZ and neo which results in the deletion of a portion of exon 3 and all of exons 4 through 7. The targeted region encoded amino acids 200 through 1380, corresponding to the protein kinase A and leucine zipper domains. |
| Phenotypic information | None. |
| Breeding history | More than 10 backcrosses on C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- Activating transcription factor 1 and CREB are important for cell survival during early mouse development.;Bleckmann Susanne C, Blendy Julie A, Rudolph Dorothea, Monaghan A Paula, Schmid Wolfgang, Schütz Günther, ;2002;Molecular and cellular biology;22;1919-25; 11865068
- Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1.;Seneviratne Anusha, Han Yumeng, Wong Eunice, Walter Edward R H, Jiang Lijun, Cave Luke, Long Nicholas J, Carling David, Mason Justin C, Haskard Dorian O, Boyle Joseph J, ;2020;Circulation research;127;928-944; 32611235