STOCK Selenontm1.2Mred/Orl

Status

Available to order

EMMA IDEM:02138
International strain nameSTOCK Selenontm1.2Mred/Orl
Alternative nameSEPN1 -/- (K51-326 L-)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolSelenontm1.2Mred,
Gene/Transgene symbolSelenon

Information from provider

ProviderAlain Lescure
Provider affiliationCNRS - Universite Louis Pasteur
Genetic informationDeletion of the third exon by cre-induced recombination leading to a frameshift and premature stop of translation in exon 6.
Phenotypic informationUnder investigation. No direct muscular defects observed, but possibly induced by sub-optimal vitamin E supply.
Breeding history1 backcross to C57BL/6J.
References
  • Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.;Rederstorff Mathieu, Castets Perrine, Arbogast Sandrine, Lainé Jeanne, Vassilopoulos Stéphane, Beuvin Maud, Dubourg Odile, Vignaud Alban, Ferry Arnaud, Krol Alain, Allamand Valérie, Guicheney Pascale, Ferreiro Ana, Lescure Alain, ;2011;PloS one;6;e23094; 21858002
  • Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency.;Castets Perrine, Bertrand Anne T, Beuvin Maud, Ferry Arnaud, Le Grand Fabien, Castets Marie, Chazot Guillaume, Rederstorff Mathieu, Krol Alain, Lescure Alain, Romero Norma B, Guicheney Pascale, Allamand Valérie, ;2011;Human molecular genetics;20;694-704; 21131290
  • Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors.;Castets Perrine, Maugenre Svetlana, Gartioux Corine, Rederstorff Mathieu, Krol Alain, Lescure Alain, Tajbakhsh Shahragim, Allamand Valérie, Guicheney Pascale, ;2009;BMC developmental biology;9;46; 19698141

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal muscle regeneration / MGI
  • abnormal muscle physiology / MGI
  • decreased satellite cell number / MGI
  • skeletal muscle atrophy / MGI
  • kyphosis / MGI
  • abnormal skeletal muscle morphology / MGI
  • decreased skeletal muscle mass / MGI
  • decreased skeletal muscle fiber size / MGI
  • decreased skeletal muscle fiber diameter / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • abnormal skeletal muscle fiber type ratio / MGI
  • decreased gastrocnemius weight / MGI
  • decreased extensor digitorum longus weight / MGI
  • decreased soleus weight / MGI
  • decreased tibialis anterior weight / MGI
  • decreased susceptibility to weight gain / MGI
  • decreased quadriceps weight / MGI

Literature references

  • Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.;Rederstorff Mathieu, Castets Perrine, Arbogast Sandrine, Lainé Jeanne, Vassilopoulos Stéphane, Beuvin Maud, Dubourg Odile, Vignaud Alban, Ferry Arnaud, Krol Alain, Allamand Valérie, Guicheney Pascale, Ferreiro Ana, Lescure Alain, ;2011;PloS one;6;e23094; 21858002
  • Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency.;Castets Perrine, Bertrand Anne T, Beuvin Maud, Ferry Arnaud, Le Grand Fabien, Castets Marie, Chazot Guillaume, Rederstorff Mathieu, Krol Alain, Lescure Alain, Romero Norma B, Guicheney Pascale, Allamand Valérie, ;2011;Human molecular genetics;20;694-704; 21131290
  • Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors.;Castets Perrine, Maugenre Svetlana, Gartioux Corine, Rederstorff Mathieu, Krol Alain, Lescure Alain, Tajbakhsh Shahragim, Allamand Valérie, Guicheney Pascale, ;2009;BMC developmental biology;9;46; 19698141

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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