MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
FVB.129P2-Peg12tm1Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02142 |
| Citation information | RRID:IMSR_EM:02142 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB.129P2-Peg12tm1Brn/Cnrm |
| Alternative name | F3H |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Peg12tm1Brn |
| Gene/Transgene symbol | Peg12 |
Information from provider
| Provider | Renee van Amerongen |
| Provider affiliation | Netherlands Cancer Institute |
| Genetic information | The majority of the Frat3 (Peg12) coding sequence was replaced by a promoterless lacZ marker followed by a PGK-hygromycin resistance cassette. The resulting lacZ knockin allele has been imprinted, probably as a result of Frat3 being located in the Prader Willi imprinting region. |
| Phenotypic information | Homozygous knockout mice are viable, healthy and fertile without obvious abnormalities. |
| Breeding history | 129P2/OlaHsd mice were backcrossed onto FVB or C57BL/6 mice. Current generation is F12 backcross. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Frat is dispensable for canonical Wnt signaling in mammals.;van Amerongen Renée, Nawijn Martijn, Franca-Koh Jonathan, Zevenhoven John, van der Gulden Hanneke, Jonkers Jos, Berns Anton, ;2005;Genes & development;19;425-30; 15681612