FVB.129P2-Peg12tm1Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:02142 |
| International strain name | FVB.129P2-Peg12tm1Brn/Cnrm |
| Alternative name | F3H |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Peg12tm1Brn, |
| Gene/Transgene symbol | Peg12 |
Information from provider
| Provider | Renee van Amerongen |
| Provider affiliation | Netherlands Cancer Institute |
| Genetic information | The majority of the Frat3 (Peg12) coding sequence was replaced by a promoterless lacZ marker followed by a PGK-hygromycin resistance cassette. The resulting lacZ knockin allele has been imprinted, probably as a result of Frat3 being located in the Prader Willi imprinting region. |
| Phenotypic information | Homozygous knockout mice are viable, healthy and fertile without obvious abnormalities. |
| Breeding history | 129P2/OlaHsd mice were backcrossed onto FVB or C57BL/6 mice. Current generation is F12 backcross. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Frat is dispensable for canonical Wnt signaling in mammals.;van Amerongen Renée, Nawijn Martijn, Franca-Koh Jonathan, Zevenhoven John, van der Gulden Hanneke, Jonkers Jos, Berns Anton, ;2005;Genes & development;19;425-30; 15681612