NOD.Cg-Tcratm1Mjo Tg(TcraCDC35)1Alhn/Orl

Status

Available to order

EMMA IDEM:00215
International strain nameNOD.Cg-Tcratm1Mjo Tg(TcraCDC35)1Alhn/Orl
Alternative nameA8 Ca-/- NOD
Strain typeTransgenic Strains
Allele/Transgene symbolTg(TcraCDC35)1Alhn,
Gene/Transgene symbolTg(TcraCDC35)1Alhn

Information from provider

ProviderAgnes LEHUEN
Provider affiliationU561, Hopital Saint-Vincent-de-Paul, Paris
Genetic informationAlpha chain of T-cell receptor Va8-Ja37; endogenous alpha chains are knocked out.
Phenotypic informationExpression of only one TCR alpha chain.
References
  • Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.;Mars Lennart T, Laloux Véronique, Goude Karine, Desbois Sabine, Saoudi Abdelhadi, Van Kaer Luc, Lassmann Hans, Herbelin André, Lehuen Agnès, Liblau Roland S, ;2002;Journal of immunology (Baltimore, Md. : 1950);168;6007-11; 12055208

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal T cell physiology / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • immune system phenotype / MGI
  • increased activated T cell number / MGI
  • rectal prolapse / MGI
  • abnormal colon morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • colitis / MGI
  • increased T cell number / MGI
  • diarrhea / MGI
  • decreased T cell proliferation / MGI
  • increased gamma-delta T cell number / MGI
  • enlarged mesenteric lymph nodes / MGI
  • abnormal neuron proliferation / MGI
  • abnormal thymus cortex morphology / MGI
  • increased immunoglobulin level / MGI
  • increased IgE level / MGI
  • abnormal immune system organ morphology / MGI
  • increased autoantibody level / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased B cell number / MGI
  • abnormal T cell morphology / MGI
  • small Peyer's patches / MGI
  • increased IgG1 level / MGI
  • abnormal splenic cell ratio / MGI
  • absent thymus medulla / MGI
  • enlarged thymus cortex / MGI
  • abnormal kidney morphology / MGI
  • increased urine protein level / MGI

Literature references

  • Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.;Mars Lennart T, Laloux Véronique, Goude Karine, Desbois Sabine, Saoudi Abdelhadi, Van Kaer Luc, Lassmann Hans, Herbelin André, Lehuen Agnès, Liblau Roland S, ;2002;Journal of immunology (Baltimore, Md. : 1950);168;6007-11; 12055208

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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