B6;129S7-Prnptm1Cwe Tg(Igh-6H4Vh/Ighm*a)508Zbz/Cnrm

Status

Available to order

EMMA IDEM:02153
International strain nameB6;129S7-Prnptm1Cwe Tg(Igh-6H4Vh/Ighm*a)508Zbz/Cnrm
Alternative nameTgN(6H4u)508
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPrnptm1Cwe,
Gene/Transgene symbolPrnp

Information from provider

ProviderFrank Heppner
Provider affiliationInstitute of Neuropathology
Genetic informationTransgene expressing the heavy chain of anti-PrP 6H4 antibody (6H4u) on a Prnp-/- background.
Phenotypic informationMice are kept hemizygous. No major defects.
Breeding historyMaintenance breedings: TgN(6H4u)508 mice are crossed with Prnp-/- mice (on C57BL/6 x 129/Sv background, Zurich colony).
References
  • Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.;Heppner F L, Musahl C, Arrighi I, Klein M A, Rülicke T, Oesch B, Zinkernagel R M, Kalinke U, Aguzzi A, ;2001;Science (New York, N.Y.);294;178-82; 11546838

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • reduced long term potentiation / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal inhibitory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • decreased brain copper level / MGI
  • tremors / MGI
  • abnormal cerebellum morphology / MGI
  • decreased Purkinje cell number / MGI

Literature references

  • Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.;Heppner F L, Musahl C, Arrighi I, Klein M A, Rülicke T, Oesch B, Zinkernagel R M, Kalinke U, Aguzzi A, ;2001;Science (New York, N.Y.);294;178-82; 11546838

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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