- reduced long term potentiation / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal inhibitory postsynaptic potential / MGI
- abnormal inhibitory postsynaptic currents / MGI
- behavior/neurological phenotype / MGI
- decreased brain copper level / MGI
- tremors / MGI
- abnormal cerebellum morphology / MGI
- decreased Purkinje cell number / MGI
B6;129S7-Prnptm1Cwe Tg(Igh-6H4Vh/Ighm*a)762Zbz/Cnrm
Status | Available to order |
EMMA ID | EM:02155 |
International strain name | B6;129S7-Prnptm1Cwe Tg(Igh-6H4Vh/Ighm*a)762Zbz/Cnrm |
Alternative name | TgN(6H4ul)762 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Prnptm1Cwe, |
Gene/Transgene symbol | Prnp |
Information from provider
Provider | Frank Heppner |
Provider affiliation | Institute of Neuropathology |
Genetic information | Transgene expressing the heavy and light chain of anti-PrP antibody (6H4ul) on a Prnp-/- background. |
Phenotypic information | Mice are kept hemizygous. No major defects. |
Breeding history | Backcrossing: 5 times to C57BL/6 x 129/Sv background. Maintenance breedings: TgN(6H4ul)762 mice are crossed with Prnp-/- mice (on C57BL/6 x 129/Sv background, Zurich colony). |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Inherited Creutzfeldt-Jakob disease / Orphanet_282166
- Familial Alzheimer-like prion disease / Orphanet_280397
- Huntington disease-like 1 / Orphanet_157941
- PrP systemic amyloidosis / Orphanet_397606
- Fatal familial insomnia / Orphanet_466
- Gerstmann-Straussler-Scheinker syndrome / Orphanet_356
- Sporadic fatal insomnia / Orphanet_586130
MGI phenotypes (allele matching)
Literature references
- Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.;Heppner F L, Musahl C, Arrighi I, Klein M A, Rülicke T, Oesch B, Zinkernagel R M, Kalinke U, Aguzzi A, ;2001;Science (New York, N.Y.);294;178-82; 11546838
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