C57BL/6Apb-Zap70mur/ApbH
Status | Available to order |
EMMA ID | EM:02170 |
International strain name | C57BL/6Apb-Zap70mur/ApbH |
Alternative name | Murdoch, C57BL/6Apb-Zap70 |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | Zap70mur, |
Gene/Transgene symbol | Zap70 |
Information from provider
Provider | Chris Goodnow |
Provider affiliation | The Australian National University |
Genetic information | This stock carries A to T point mutation at nucleotide 1190 (I366F) resulting in protein domain inactivation. This strain was identified during systematically screening of the mouse genome for autoimmune regulators. This mutant strain develops fewer CD4 and CD8 positive cells and autoimmunity. The strain has a similar phenotype to the published gene knock-outs mutants. This strain may assist in the understanding of the molecular requirements for the development of autoimmune disease. |
Phenotypic information | This strain has the following phenotypic effects: Reduced naive CD4+ and CD8+ T cells which are hyperactivated, reduced CD4+ cells, defect in TCR signal transduction, impaired but not severe response to anti-TCR stimulation, T cell intrinsic defect, elevated serum levels of IgG2b. |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined immunodeficiency due to ZAP70 deficiency / Orphanet_911
MGI phenotypes (allele matching)
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