C57BL/6-Tg(KRT5-Trp63_ideltaN)1Gml/Cnrm
| Status | Available to order |
| EMMA ID | EM:02284 |
| International strain name | C57BL/6-Tg(KRT5-Trp63_ideltaN)1Gml/Cnrm |
| Alternative name | Tg:DeltaNp63alpha-HA |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT5-Trp63_ideltaN)1Gml, |
| Gene/Transgene symbol | Tg(KRT5-Trp63_ideltaN)1Gml |
Information from provider
| Provider | Gerry Melino |
| Provider affiliation | University of Tor Vergata |
| Genetic information | A recombination vector containing the K5 promoter (from Dr Manfred Blessing, Joannes Gutemberg University, Mainz, Germany) and the PolyA+ signal was used. Mouse DeltaNp63alpha cDNA was tagged at the N-terminus (hemagglutinin-antigen, HA) and cloned into the vector using ClaI restriction sites located between the promoter and the polyA+ cassette. The fragment containing the expression cassette (K5promoter/DeltaNp63alpha/ polyA+ signal) was released using KpnI. |
| Phenotypic information | None. |
| Breeding history | Heterozygous mice are bred with wild-type mice and transgenic mice are selected upon genotype screening. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.;Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli L G, Catani M V, Ramadan S, Knight R A, Melino G, ;2006;Cell death and differentiation;13;1037-47; 16601749
- DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.;Candi Eleonora, Rufini Alessandro, Terrinoni Alessandro, Giamboi-Miraglia Alessandro, Lena Anna Maria, Mantovani Roberto, Knight Richard, Melino Gerry, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;11999-2004; 17626181