MGI phenotypes (allele matching)
B6;129P2-Mc2rtm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02299 |
| International strain name | B6;129P2-Mc2rtm1Dgen/H |
| Alternative name | DELTAGEN_T605 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mc2rtm1Dgen, |
| Gene/Transgene symbol | Mc2r |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Histopathology: Adrenal gland, hypoplasia (cortex and medulla); Brown adipose tissue, decreased cytoplasmic lipid vacuolation. Densitometry : Low fat % in homozygous mutant females. Behavior: Decreased metrazol response threshold; Increased total distance traveled in open field test; Decreased time immobile on tail suspension test. Changes related to genotype at 300 days: Histopathology : Adrenal gland, hypoplasia (cortex); Brown adipose tissue, decreased cytoplasmic lipid vacuolation. Densitometry : Low fat % in homozygous mutant females. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial glucocorticoid deficiency / Orphanet_361