B6;129S5-Rras2Gt(OST47398)Lex/Ieg
Status | Available to order |
EMMA ID | EM:02326 |
International strain name | B6;129S5-Rras2Gt(OST47398)Lex/Ieg |
Alternative name | LEXKO-648, RASTC21_1 |
Strain type | Gene-trap |
Allele/Transgene symbol | Rras2Gt(OST47398)Lex, |
Gene/Transgene symbol | Rras2 |
Information from provider
Provider | Lexicon Genetics, Inc. |
Provider affiliation | Lexicon Pharmaceuticals |
Phenotypic information | Ophthalmic observations found reduced mean artery-to-vein ratio in the homozygous mutant mice as compared to wild-type littermates. In microscopic examination, homozygotes showed signs of retinal degeneration characterized by a reduction in thickness of external nuclear and photoreceptor layers as well as vacuolization of photoreceptor and external plexiorm layers. The male homozygotes also had a higher mean total tissue mass and mean total body fat as compared to the gender-matched wild-type littermates. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Noonan syndrome / Orphanet_648
MGI phenotypes (allele matching)
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