IMPC phenotypes (gene matching)
B6;129S5-Rras2Gt(OST47398)Lex/Ieg
| Status | Available to order |
| EMMA ID | EM:02326 |
| Citation information | RRID:IMSR_EM:02326 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S5-Rras2Gt(OST47398)Lex/Ieg |
| Alternative name | LEXKO-648, RASTC21_1 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Rras2Gt(OST47398)Lex |
| Gene/Transgene symbol | Rras2 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | Ophthalmic observations found reduced mean artery-to-vein ratio in the homozygous mutant mice as compared to wild-type littermates. In microscopic examination, homozygotes showed signs of retinal degeneration characterized by a reduction in thickness of external nuclear and photoreceptor layers as well as vacuolization of photoreceptor and external plexiorm layers. The male homozygotes also had a higher mean total tissue mass and mean total body fat as compared to the gender-matched wild-type littermates. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Noonan syndrome / Orphanet_648
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- spleen hypoplasia / MGI
- increased body size / MGI
- retinal degeneration / MGI
- abnormal dendritic cell physiology / MGI
- abnormal B cell physiology / MGI
- abnormal retinal vasculature morphology / MGI
- maternal effect / MGI
- increased tumor growth/size / MGI
- abnormal retinal photoreceptor layer morphology / MGI
- abnormal retinal outer plexiform layer morphology / MGI
- abnormal CD8-positive, alpha-beta T cell physiology / MGI
- decreased spleen weight / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- decreased B cell proliferation / MGI
- immune system phenotype / MGI
- abnormal dendritic cell morphology / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- decreased memory T cell number / MGI
- decreased follicular B cell number / MGI
- decreased marginal zone B cell number / MGI
- abnormal B cell activation / MGI
- abnormal spleen B cell follicle morphology / MGI
- thin retinal outer nuclear layer / MGI
- abnormal lymph node germinal center morphology / MGI
- increased total body fat amount / MGI