B6;129S5-Gria1tm1Lex/Ieg

Status

Available to order

EMMA IDEM:02335
Citation informationRRID:IMSR_EM:02335 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6;129S5-Gria1tm1Lex/Ieg
Alternative nameLEXKO-1520, CHA355C1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGria1tm1Lex
Gene/Transgene symbolGria1

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationThe homozygous mutant mice exhibited notably increased locomotor activity during open field testing and numerous other neurological abnormalities when compared with the measurements for their gender-matched wild-type littermates and the historical means. The mutants also exhibited increased mean serum blood urea nitrogen levels, and the female mutants exhibited a decreased median serum HgbA1c level.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • increased circulating amylase level / IMPC
  • decreased freezing behavior / IMPC
  • decreased exploration in new environment / IMPC
  • increased circulating serum albumin level / IMPC
  • decreased prepulse inhibition / IMPC
  • increased blood urea nitrogen level / IMPC
  • impaired contextual conditioning behavior / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal freezing behavior / IMPC
  • abnormal gait / IMPC
  • impaired cued conditioning behavior / IMPC
  • increased circulating iron level / IMPC
  • increased mechanical nociceptive threshold / IMPC
  • abnormal locomotor behavior / IMPC
  • decreased bone mineral content / IMPC
  • decreased vertical activity / IMPC
  • hypoalgesia / IMPC
  • decreased startle reflex / IMPC
MGI phenotypes (allele matching)
  • hyperactivity / MGI
  • increased blood urea nitrogen level / MGI
  • decreased glycosylated hemoglobin level / MGI
MGI phenotypes (gene matching)
  • abnormal spinal cord morphology / MGI
  • decreased body size / MGI
  • abnormal social investigation / MGI
  • increased anxiety-related response / MGI
  • decreased anxiety-related response / MGI
  • abnormal locomotor behavior / MGI
  • hyperactivity / MGI
  • abnormal response to new environment / MGI
  • increased exploration in new environment / MGI
  • reduced long term potentiation / MGI
  • absent long term depression / MGI
  • impaired synaptic plasticity / MGI
  • abnormal associative learning / MGI
  • no abnormal phenotype detected / MGI
  • abnormal long term potentiation / MGI
  • abnormal sexual interaction / MGI
  • abnormal emotion/affect behavior / MGI
  • increased vertical activity / MGI
  • abnormal nociception after inflammation / MGI
  • no phenotypic analysis / MGI
  • nervous system phenotype / MGI
  • decreased aggression towards males / MGI
  • abnormal serotonin level / MGI
  • homeostasis/metabolism phenotype / MGI
  • behavior/neurological phenotype / MGI
  • increased blood urea nitrogen level / MGI
  • decreased glycosylated hemoglobin level / MGI
  • abnormal dendrite morphology / MGI
  • abnormal long term spatial reference memory / MGI
  • decreased chemical nociceptive threshold / MGI
  • induced hyperactivity / MGI
  • abnormal behavioral response to xenobiotic / MGI
  • decreased behavioral withdrawal response / MGI
  • reduced AMPA-mediated synaptic currents / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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