IMPC phenotypes (gene matching)
B6;129S5-Gria2tm1Lex/Ieg
| Status | Available to order |
| EMMA ID | EM:02336 |
| Citation information | RRID:IMSR_EM:02336 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S5-Gria2tm1Lex/Ieg |
| Alternative name | LEXKO-1605, CHA356C1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gria2tm1Lex |
| Gene/Transgene symbol | Gria2 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The homozygous mutant mice exhibited numerous neurological abnormalities when compared with their wild-type littermates and the historical means, including an abnormal sleep/wake cycle, decreased exploratory and locomotor activity, and a motor strength deficit. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
- hippocampal neuron degeneration / MGI
- abnormal spinal cord morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- hyperactivity / MGI
- jumpy / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- decreased exploration in new environment / MGI
- abnormal grooming behavior / MGI
- decreased grooming behavior / MGI
- postnatal growth retardation / MGI
- absent long term depression / MGI
- impaired synaptic plasticity / MGI
- abnormal reflex / MGI
- abnormal touch/ nociception / MGI
- seizures / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal emotion/affect behavior / MGI
- abnormal nociception after inflammation / MGI
- abnormal AMPA-mediated synaptic currents / MGI
- abnormal excitatory postsynaptic potential / MGI
- enhanced long term potentiation / MGI
- no phenotypic analysis / MGI
- abnormal response to novel object / MGI
- nervous system phenotype / MGI
- tonic-clonic seizures / MGI
- abnormal limb posture / MGI
- lethargy / MGI
- hearing/vestibular/ear phenotype / MGI
- hyperalgesia / MGI
- abnormal cell physiology / MGI
- increased susceptibility to neuronal excitotoxicity / MGI
- abnormal hippocampus CA3 region morphology / MGI
- decreased chemical nociceptive threshold / MGI
- paraparesis / MGI
- decreased grip strength / MGI
- enhanced AMPA-mediated synaptic currents / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal circadian sleep/wake cycle / MGI