IMPC phenotypes (gene matching)
B6;129S5-Trib2tm1Lex/Orl
| Status | Available to order |
| EMMA ID | EM:02347 |
| Citation information | RRID:IMSR_EM:02347 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S5-Trib2tm1Lex/Orl |
| Alternative name | LEXKO-1136 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trib2tm1Lex |
| Gene/Transgene symbol | Trib2 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The homozygous mutant mice exhibited an increased mean percentage of CD8 cells and a decreased mean percentage of B cells in the peripheral blood when compared with their wild-type littermates and the historical means. The mutants also exhibited decreased exploratory activity during open field activity testing. |
| Breeding history | It seems the homozygous females are not very fertile and the best procedure is to cross homozygous males with heterozygous females. |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- tremors / MGI
- abnormal hippocampus morphology / MGI
- decreased body weight / MGI
- impaired coordination / MGI
- decreased exploration in new environment / MGI
- reduced long term potentiation / MGI
- abnormal posture / MGI
- limb grasping / MGI
- impaired righting response / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- gliosis / MGI
- abnormal CNS synaptic transmission / MGI
- decreased vertical activity / MGI
- abnormal excitatory postsynaptic potential / MGI
- amyloid beta deposits / MGI
- astrocytosis / MGI
- abnormal behavior / MGI
- decreased B cell number / MGI
- hematopoietic system phenotype / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal hippocampus CA1 region morphology / MGI
- slow postnatal weight gain / MGI
- microgliosis / MGI
- decreased prepulse inhibition / MGI
- decreased hippocampus pyramidal cell number / MGI
- hippocampus pyramidal cell degeneration / MGI
- decreased food intake / MGI
- decreased fluid intake / MGI