IMPC phenotypes (gene matching)
B6;129S5-Il25tm1Lex/Orl
| Status | Available to order |
| EMMA ID | EM:02348 |
| Citation information | RRID:IMSR_EM:02348 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S5-Il25tm1Lex/Orl |
| Alternative name | LEXKO-0310 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Il25tm1Lex |
| Gene/Transgene symbol | Il25 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The male homozygous mutant mice exhibited notably increased mean serum triglyceride levels when compared with their gender-matched wild-type littermates and the historical mean. No other notable phenotype was observed for the homozygous mutant mice. |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased circulating triglyceride level / MGI
MGI phenotypes (gene matching)
- abnormal crypts of Lieberkuhn morphology / MGI
- abnormal colon morphology / MGI
- increased circulating triglyceride level / MGI
- intestinal inflammation / MGI
- lung inflammation / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgE level / MGI
- no phenotypic analysis / MGI
- abnormal intestinal goblet cell morphology / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased eosinophil cell number / MGI
- increased T cell number / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal mesenteric lymph node morphology / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased T-helper 2 cell number / MGI
- decreased IgG2a level / MGI
- decreased susceptibility to induced colitis / MGI
- decreased tumor necrosis factor secretion / MGI
- abnormal interleukin secretion / MGI
- decreased interleukin-1 beta secretion / MGI
- decreased interleukin-13 secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased interleukin-5 secretion / MGI
- decreased interleukin-9 secretion / MGI
- abnormal chemokine secretion / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased susceptibility to weight loss / MGI