MGI phenotypes (allele matching)
- increased NK cell number / MGI
B6;129S5-Tnfsf15tm1Lex/Ieg
| Status | Available to order |
| EMMA ID | EM:02353 |
| Citation information | RRID:IMSR_EM:02353 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S5-Tnfsf15tm1Lex/Ieg |
| Alternative name | LEXKO-1554, MAS278N1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tnfsf15tm1Lex |
| Gene/Transgene symbol | Tnfsf15 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The homozygous mutant mice exhibited an increased mean percentage of natural killer cells in peripheral blood when compared with that of their wild-type littermates and the historical means. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased IgG level / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- immune system phenotype / MGI
- increased NK cell number / MGI
- decreased plasma cell number / MGI
- lymph node hypoplasia / MGI
- abnormal dendritic cell differentiation / MGI
- decreased germinal center B cell number / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased T follicular helper cell number / MGI