MGI phenotypes (allele matching)
B6;129P2-Grm1tm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02357 |
| International strain name | B6;129P2-Grm1tm1Dgen/H |
| Alternative name | DELTAGEN_T801 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Grm1tm1Dgen, |
| Gene/Transgene symbol | Grm1 |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Home cage observations: ataxia/lack of coordination, stumbling, paddling movements, hypoactivity, thin, and/or hunched posture, 20 and 49 day cohorts. Physical examination: ataxia, incoordination, runted, thinness and weakness in homozygous mutant mice, 49 day cohort. Necropsy examination: decreased body weights and body lengths in homozygous mutant mice at 49 days. Mouse metrics: decreased body weight, body length, and body weight/body length ratio in a homozygous mutant mouse, 49 day cohort. Juvenile lethality: homozygous mutant mice do not survive to 90 day cohort. There were no significant differences detected in the heterozygous mutant mice when compared with age- and gender-matched wild-type control mice. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency / Orphanet_324262