MGI phenotypes (allele matching)
B6;129P2-Grm1tm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02357 |
| Citation information | RRID:IMSR_EM:02357 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Grm1tm1Dgen/H |
| Alternative name | DELTAGEN_T801 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Grm1tm1Dgen |
| Gene/Transgene symbol | Grm1 |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Home cage observations: ataxia/lack of coordination, stumbling, paddling movements, hypoactivity, thin, and/or hunched posture, 20 and 49 day cohorts. Physical examination: ataxia, incoordination, runted, thinness and weakness in homozygous mutant mice, 49 day cohort. Necropsy examination: decreased body weights and body lengths in homozygous mutant mice at 49 days. Mouse metrics: decreased body weight, body length, and body weight/body length ratio in a homozygous mutant mouse, 49 day cohort. Juvenile lethality: homozygous mutant mice do not survive to 90 day cohort. There were no significant differences detected in the heterozygous mutant mice when compared with age- and gender-matched wild-type control mice. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency / Orphanet_324262
MGI phenotypes (gene matching)
- increased brown adipose tissue amount / MGI
- decreased bone mineral density / MGI
- kyphoscoliosis / MGI
- kyphosis / MGI
- muscle spasm / MGI
- tremors / MGI
- weakness / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- ataxia / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- decreased exploration in new environment / MGI
- abnormal spatial learning / MGI
- abnormal contextual conditioning behavior / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- hunched posture / MGI
- limb grasping / MGI
- impaired righting response / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- reduced fertility / MGI
- reduced female fertility / MGI
- male infertility / MGI
- premature death / MGI
- abnormal fertility/fecundity / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal sexual interaction / MGI
- albuminuria / MGI
- abnormal excitatory postsynaptic currents / MGI
- nervous system phenotype / MGI
- abnormal proximal convoluted tubule morphology / MGI
- increased susceptibility to injury / MGI
- glomerulosclerosis / MGI
- narrow eye opening / MGI
- abnormal podocyte morphology / MGI
- behavior/neurological phenotype / MGI
- podocyte foot process effacement / MGI
- decreased bone mineral content / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- abnormal glomerular filtration barrier function / MGI
- abnormal electroretinogram waveform feature / MGI