| Status | Available to order |
| EMMA ID | EM:02361 |
| International strain name | B6;129P2-Slc7a10tm1Dgen/H |
| Alternative name | DELTAGEN_T1778 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Slc7a10tm1Dgen, |
| Gene/Transgene symbol | Slc7a10 |
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Perinatal Lethality: Homozygous mice frequently did not survive to weaning age. Home Cage Observation: Body Shape: Runted, 20 day homozygous males. Movement: Tremors, seizures, and stumbling, 20 day homozygous females and males. Physical Examination: Changes that may be related to genotype: Locomotor: Hypoactivity, 20 day homozygous male. Tremors, 49 day homozygous male. General: Hunched posture, 20 day homozygous females and males. Respirations: Rapid, 20 day homozygous female. Body Shape: Runted, 20 day homozygous male. Densitometer: Total tissue mass, low, 49 day homozygous female and males. Necropsy: Body weight, low, 20 day homozygous females and male, 49 day homozygous males. Spleen, weight and organ weight to body weight ratio, low, 20 day homozygous females and males. Thymus, weight and organ weight to body weight ratio, low, 20 day homozygous females and/or male. Behavior: Heterozygous mutant mice required a significantly higher dose of metrazol to reach various seizure stages when compared with age- and gender-matched wild-type control mice. There were no significant differences detected in the heterozygous mutant mice when compared with age- and gender-matched wild-type control mice. Homozygous mice frequently did not survive to weaning age. The findings suggested a perinatal lethal phenotype. |
| References | None available |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
