- decreased heart rate / MGI
- abnormal mammary gland growth during pregnancy / MGI
- small ovary / MGI
- abnormal ovarian follicle morphology / MGI
- absent corpus luteum / MGI
- abnormal spermatogenesis / MGI
- decreased body weight / MGI
- abnormal cardiovascular system physiology / MGI
- postnatal growth retardation / MGI
- male infertility / MGI
- female infertility / MGI
- ovary cysts / MGI
- small heart / MGI
- shortened QT interval / MGI
- abnormal atrioventricular bundle conduction / MGI
- decreased testis weight / MGI
- azoospermia / MGI
- abnormal spermatocyte morphology / MGI
- prolonged QRS complex duration / MGI
- postnatal lethality, incomplete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
B6.129P2(SJL)-Gja1tm7(Gja2)Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:02385 |
International strain name | B6.129P2(SJL)-Gja1tm7(Gja2)Kwi/Cnrm |
Alternative name | Cx43KICx26 |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Gja1tm7(Gja2)Kwi, |
Gene/Transgene symbol | Gja1 |
Information from provider
Provider | Klaus WILLECKE |
Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
Genetic information | Instead of the whole open reading frame of exon 2 of Cx43 (Gja1) the coding region of Cx26 is inserted; one frt site, 3' of the poly(A)-signal, is remaining in the genome, upon deletion of the frt sites-flanked neomycin selection cassette. |
Phenotypic information | Heterozygous females have lactation difficulties, homozygous mice are infertile. |
Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown offspring. This brown offspring was backcrossed once with flp recombinase deleter mice (nearly 100% C57BL/6NCrl) to delete the selection cassette and after that more than three times with C57BL/6NCrl. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant palmoplantar keratoderma and congenital alopecia / Orphanet_1010
- Oculodentodigital dysplasia / Orphanet_2710
- Craniometaphyseal dysplasia / Orphanet_1522
- Syndactyly type 3 / Orphanet_93404
- Erythrokeratodermia variabilis / Orphanet_317
MGI phenotypes (allele matching)
Literature references
- Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart.;Winterhager Elke, Pielensticker Nicole, Freyer Jennifer, Ghanem Alexander, Schrickel Jan W, Kim Jung-Sun, Behr Rüdiger, Grümmer Ruth, Maass Karen, Urschel Stephanie, Lewalter Thorsten, Tiemann Klaus, Simoni Manuela, Willecke Klaus, ;2007;BMC developmental biology;7;26; 17408477
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