B6;129-Grem1tm1Azun/Cnrm

Status

Available to order

EMMA IDEM:02399
International strain nameB6;129-Grem1tm1Azun/Cnrm
Alternative nameGrem1 delta-Zllr
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGrem1tm1Azun,
Gene/Transgene symbolGrem1

Information from provider

ProviderRolf Zeller
Provider affiliationDBM Centre for Biomedicine
Genetic informationThe entire 552-bases ORF encoded by exon 2 and 132 bases of the 3' UTR were deleted and replaced by an IRES-lacZ and a floxed neo. For details see: Michos O., Panman L., Vintersten K., Beier K., Zeller R. and Zuniga A. (2004). Gremlin mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131, 3401-3410.
Phenotypic informationLoss of digit identities, lung epithelial defects, bilateral renal aplasia.
References
  • Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.;Michos Odyssé, Panman Lia, Vintersten Kristina, Beier Konstantin, Zeller Rolf, Zuniga Aimée, ;2004;Development (Cambridge, England);131;3401-10; 15201225
  • Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis.;Michos Odyssé, Gonçalves Alexandre, Lopez-Rios Javier, Tiecke Eva, Naillat Florence, Beier Konstantin, Galli Antonella, Vainio Seppo, Zeller Rolf, ;2007;Development (Cambridge, England);134;2397-405; 17522159

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • absent kidney / MGI
  • single kidney / MGI
  • abnormal urinary bladder morphology / MGI
  • oligodactyly / MGI
  • cyanosis / MGI
  • abnormal apical ectodermal ridge morphology / MGI
  • respiratory distress / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • absent ureter / MGI
  • fused metacarpal bones / MGI
  • impaired branching involved in ureteric bud morphogenesis / MGI
  • increased apoptosis / MGI
  • abnormal limb development / MGI
  • abnormal lung epithelium morphology / MGI
  • abnormal ureteric bud elongation / MGI
  • abnormal ureteric bud invasion / MGI
  • abnormal metanephric mesenchyme morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • abnormal limb mesenchyme morphology / MGI
  • absent metanephros / MGI
  • increased metanephric mesenchyme apoptosis / MGI
  • abnormal limb long bone morphology / MGI

Literature references

  • Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.;Michos Odyssé, Panman Lia, Vintersten Kristina, Beier Konstantin, Zeller Rolf, Zuniga Aimée, ;2004;Development (Cambridge, England);131;3401-10; 15201225
  • Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis.;Michos Odyssé, Gonçalves Alexandre, Lopez-Rios Javier, Tiecke Eva, Naillat Florence, Beier Konstantin, Galli Antonella, Vainio Seppo, Zeller Rolf, ;2007;Development (Cambridge, England);134;2397-405; 17522159

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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