- absent kidney / MGI
- single kidney / MGI
- abnormal urinary bladder morphology / MGI
- oligodactyly / MGI
- cyanosis / MGI
- abnormal apical ectodermal ridge morphology / MGI
- respiratory distress / MGI
- abnormal pulmonary alveolus morphology / MGI
- absent ureter / MGI
- fused metacarpal bones / MGI
- impaired branching involved in ureteric bud morphogenesis / MGI
- increased apoptosis / MGI
- abnormal limb development / MGI
- abnormal lung epithelium morphology / MGI
- abnormal ureteric bud elongation / MGI
- abnormal ureteric bud invasion / MGI
- abnormal metanephric mesenchyme morphology / MGI
- neonatal lethality, complete penetrance / MGI
- abnormal limb mesenchyme morphology / MGI
- absent metanephros / MGI
- increased metanephric mesenchyme apoptosis / MGI
- abnormal limb long bone morphology / MGI
B6;129-Grem1tm1Azun/Cnrm
Status | Available to order |
EMMA ID | EM:02399 |
International strain name | B6;129-Grem1tm1Azun/Cnrm |
Alternative name | Grem1 delta-Zllr |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Grem1tm1Azun, |
Gene/Transgene symbol | Grem1 |
Information from provider
Provider | Rolf Zeller |
Provider affiliation | DBM Centre for Biomedicine |
Genetic information | The entire 552-bases ORF encoded by exon 2 and 132 bases of the 3' UTR were deleted and replaced by an IRES-lacZ and a floxed neo. For details see: Michos O., Panman L., Vintersten K., Beier K., Zeller R. and Zuniga A. (2004). Gremlin mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131, 3401-3410. |
Phenotypic information | Loss of digit identities, lung epithelial defects, bilateral renal aplasia. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary mixed polyposis syndrome / Orphanet_157794
MGI phenotypes (allele matching)
Literature references
- Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.;Michos Odyssé, Panman Lia, Vintersten Kristina, Beier Konstantin, Zeller Rolf, Zuniga Aimée, ;2004;Development (Cambridge, England);131;3401-10; 15201225
- Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis.;Michos Odyssé, Gonçalves Alexandre, Lopez-Rios Javier, Tiecke Eva, Naillat Florence, Beier Konstantin, Galli Antonella, Vainio Seppo, Zeller Rolf, ;2007;Development (Cambridge, England);134;2397-405; 17522159
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