B6.Cg-Tg(APOA4)8018Feb/Cnrm
Status | Available to order |
EMMA ID | EM:00024 |
International strain name | B6.Cg-Tg(APOA4)8018Feb/Cnrm |
Alternative name | APOA4-Tg#8018 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(APOA4)8018Feb, |
Gene/Transgene symbol | Tg(APOA4)8018Feb |
Information from provider
Provider | Francisco E. Baralle |
Provider affiliation | ICGEB-Inter.Centre Genetic Engineering Biotechnology |
Genetic information | The human APOA4 gene was expressed under the control of the human APOA4 promoter. Nine copies of the transgene were inserted into the genome. |
Phenotypic information | Human APOA4 protein was detected in plasma of mice carrying this transgene. Dyslipidemia and hypetriglyceridemia model, atherosclerosis model. |
Breeding history | Crossed to CD1 then backcrossed to C57BL/6 (more than 10 generations) |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
Stage of embryos | 2-cell |
Literature references
- Regulation of the human apolipoprotein AIV gene expression in transgenic mice.;Baralle M, Vergnes L, Muro A F, Zakin M M, Baralle F E, Ochoa A, ;1999;FEBS letters;445;45-52; 10069372
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