MGI phenotypes (allele matching)
B6.129S7-Del(16Cldn5-Hira)5Bld/Cnrm
| Status | Available to order |
| EMMA ID | EM:02405 |
| International strain name | B6.129S7-Del(16Cldn5-Hira)5Bld/Cnrm |
| Alternative name | RV46 |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Del(16Cldn5-Hira)5Bld, |
| Gene/Transgene symbol | Del(16Cldn5-Hira)5Bld |
Information from provider
| Provider | Antonio BALDINI |
| Provider affiliation | institute of biosciences and technologies, Texas A&M health science center |
| Genetic information | A targeting cassette containing a loxP site was inserted into intron 25 of the endogenous Hira gene in ES cells. A second loxP site was inserted by retroviral insertion into an intragenic region between Cdcrel1 and Cld5. A deletion of ~250kb was generated by cre recombination in ES cells. |
| Phenotypic information | None in heterozygotes. |
| Breeding history | Backcrossed to C57BL/6 inbred mice for 6 generations then maintained by breeding siblings. This breeding is required to maintain a behavioral phenotype. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.;Lindsay E A, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jurecic V, Ogunrinu G, Sutherland H F, Scambler P J, Bradley A, Baldini A, ;2001;Nature;410;97-101; 11242049