IMPC phenotypes (allele matching)
129-Vimtm2Cba/Orl
| Status | Available to order |
| EMMA ID | EM:02410 |
| Citation information | RRID:IMSR_EM:02410 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Vimtm2Cba/Orl |
| Alternative name | Vim2/Vim2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Vimtm2Cba |
| Gene/Transgene symbol | Vim |
Information from provider
| Provider | Emma Colucci-Guyon |
| Provider affiliation | Institut Pasteur |
| Genetic information | Exon 1 of the vimentin gene is disrupted by insertion of a TK-neo expression cassette, which results in the inactivation of the gene. The TKneo expression cassette is kept in the mutated allele. |
| Phenotypic information | Mice devoid of vimentin develop and reproduce without any obvious defects. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pulverulent cataract / Orphanet_98984
MGI phenotypes (gene matching)
- abnormal vasoconstriction / MGI
- abnormal angiogenesis / MGI
- abnormal cell morphology / MGI
- abnormal cerebellum morphology / MGI
- abnormal cerebellar Purkinje cell layer / MGI
- Purkinje cell degeneration / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- increased anxiety-related response / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- impaired balance / MGI
- abnormal vasodilation / MGI
- abnormal blood vessel morphology / MGI
- abnormal astrocyte morphology / MGI
- abnormal motor learning / MGI
- abnormal cell migration / MGI
- abnormal leukocyte migration / MGI
- abnormal leukocyte tethering or rolling / MGI
- abnormal leukocyte adhesion / MGI
- nervous system phenotype / MGI
- decreased mean systemic arterial blood pressure / MGI
- homeostasis/metabolism phenotype / MGI
- embryo phenotype / MGI
- cellular phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- respiratory system phenotype / MGI
- reproductive system phenotype / MGI
- increased circulating creatinine level / MGI
- abnormal cell physiology / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
Literature references
- Mice lacking vimentin develop and reproduce without an obvious phenotype.;Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C, ;1994;Cell;79;679-94; 7954832