- increased granulocyte number / MGI
- abnormal spleen morphology / MGI
- spleen hypoplasia / MGI
- decreased body size / MGI
- arrested B cell differentiation / MGI
- decreased IgM level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- increased susceptibility to infection / MGI
- abnormal effector T cell morphology / MGI
- increased natural killer cell mediated cytotoxicity / MGI
- decreased double-positive T cell number / MGI
- increased macrophage cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- lymph node hypoplasia / MGI
- absent mature B cells / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal immunoglobulin V(D)J recombination / MGI
- decreased thymocyte number / MGI
- lung inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- colitis / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal response to transplant / MGI
- abnormal interferon secretion / MGI
- abnormal chemokine secretion / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal B cell morphology / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal stomach mucosa morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal B cell number / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal gamma-delta T cell differentiation / MGI
B6.Cg-Ptprca Rag2tm1Fwa Foxp3tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas/Orl
Status | Available to order |
EMMA ID | EM:02419 |
International strain name | B6.Cg-Ptprca Rag2tm1Fwa Foxp3tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas/Orl |
Alternative name | Simone |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Rag2tm1Fwa, |
Gene/Transgene symbol | Rag2 |
Information from provider
Provider | David GROSS |
Provider affiliation | INSERM U580 |
Additional owner | O. Lantz (Marilyn) and B. Malissen (Foxp3 EGFP) |
Genetic information | TCR transgenic T cells with "green" regulatory T cells (Tregs). The Foxp3 IRES-EGFP targeted knock-in allele (Foxp3 EGFP) was put on the Marilyn background. Transgenic for T(TCR)Valpha 1.1/Vbeta6 receptor specific of the H-Y male antigen presented by I-a b. The recognized peptide (NAGFNSNRANSSRSS) comes from Dby. As the clone originates from a F1 H-2b/k mouse, the TCR does not react with H-2k or H-2b. The mice of this strain are also homozygous for a Rag2 knock-out allele and Ptprca (CD45.1). An IRES-EGFP cassette was introduced in the 3'UTR region of FoxP3 gene, exon 11. The autodeleter neomycin-cre recombinase cassette was used. |
Phenotypic information | None. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome / Orphanet_37042
- T-B+ severe combined immunodeficiency due to CD45 deficiency / Orphanet_169157
- Severe combined immunodeficiency due to complete RAG1/2 deficiency / Orphanet_331206
- Omenn syndrome / Orphanet_39041
- Combined immunodeficiency with granulomatosis / Orphanet_157949
MGI phenotypes (allele matching)
Literature references
- Gamma chain required for naïve CD4+ T cell survival but not for antigen proliferation.;Lantz O, Grandjean I, Matzinger P, Di Santo J P, ;2000;Nature immunology;1;54-8; 10881175
- Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.;Wang Ying, Kissenpfennig Adrien, Mingueneau Michael, Richelme Sylvie, Perrin Pierre, Chevrier Stéphane, Genton Céline, Lucas Bruno, DiSanto James P, Acha-Orbea Hans, Malissen Bernard, Malissen Marie, ;2008;Journal of immunology (Baltimore, Md. : 1950);180;1565-75; 18209052
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