STOCK Axd/Cnrm
Status | Available to order |
EMMA ID | EM:02424 |
International strain name | STOCK Axd/Cnrm |
Alternative name | BALB/c - Axial defects |
Strain type | Spontaneous |
Allele/Transgene symbol | Axd, |
Gene/Transgene symbol | Axd |
Information from provider
Provider | Madeleine BROUNS |
Provider affiliation | Maastricht University |
Genetic information | Unknown. |
Phenotypic information | All homozygotes display curled tails and/or spina bifida. 40% of heterozygotes displays curled tails. Homozygous animals have reduced fertility. |
Breeding history | Rederived heterozygous Axial defects mice were crossed 3 consecutive times with BALB/c while selecting the dominant curled tail phenotype. Genetic background was monitored using polymorphic marker analysis. This speed congenics protocol resulted in 95% BALB/c genetic background as assessed by 63 markers evenly spread over the genome. Currently the strain is bred as a heterozygous line, maintained by crosses with wild type mice of the same genetic background. Heterozygotes are identified by their curled tail phenotype. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age.;Essien F B, Haviland M B, Naidoff A E, ;1990;Teratology;42;183-94; 2218945
- Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants.;Essien F B, ;1992;Teratology;45;205-12; 1615430
- Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice.;Essien F B, Wannberg S L, ;1993;The Journal of nutrition;123;27-34; 8421227
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