MGI phenotypes (allele matching)
CAnNCrl.GFF(CB)-Grhl3ct/Cnrm
| Status | Available to order |
| EMMA ID | EM:02425 |
| International strain name | CAnNCrl.GFF(CB)-Grhl3ct/Cnrm |
| Alternative name | BALB/c - curly tail |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Grhl3ct, |
| Gene/Transgene symbol | Grhl3 |
Information from provider
| Provider | Madeleine BROUNS |
| Provider affiliation | Maastricht University |
| Genetic information | Hypomorphic allele of grainyhead-like 3; exact mutation unknown. |
| Phenotypic information | Homozygotes display curled tails and/or spina bifida with incomplete penetrance. A small subset of homozygotes displays exencephaly. |
| Breeding history | Homozygous curly tail mice were crossed with BALB/c inbred mice. Heterozygous offspring was intercrossed. Affected (homozygous) offspring was crossed with BALB/c; 5 crosses with BALB/c were performed according to this scheme (see also PubMed_ID 15678492). The curly tail critical region present in the current strain is 1 megabase. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Van der Woude syndrome / Orphanet_888
Literature references
- Curly tail: a 50-year history of the mouse spina bifida model.;van Straaten H W, Copp A J, ;2001;Anatomy and embryology;203;225-37; 11396850
- Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.;Ting Stephen B, Wilanowski Tomasz, Auden Alana, Hall Mark, Voss Anne K, Thomas Tim, Parekh Vishwas, Cunningham John M, Jane Stephen M, ;2003;Nature medicine;9;1513-9; 14608380
- Toward positional cloning of the curly tail gene.;Brouns Madeleine R, Peeters Marian C E, Geurts Jan M, Merckx Diane M, Engelen John J, Hekking Johan W M, Terwindt-Rouwenhorst Els A W, Oosterbaan Mariet E A C, Geraedts Joep P M, van Straaten Henny W, ;2005;Birth defects research. Part A, Clinical and molecular teratology;73;154-61; 15678492
- Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.;Gustavsson Peter, Greene Nicholas D E, Lad Dina, Pauws Erwin, de Castro Sandra C P, Stanier Philip, Copp Andrew J, ;2007;Human molecular genetics;16;2640-6; 17720888