B6.129P2-Prnp/Prndtm1Aag/Cnrm

Status

Available to order

EMMA IDEM:02432
International strain nameB6.129P2-Prnp/Prndtm1Aag/Cnrm
Alternative nameC57Bl/6J-Prnd/PrnP (PrP-Dpl) double knockout mouse
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPrnp/Prndtm1Aag,
Gene/Transgene symbolPrnd

Information from provider

ProviderAdriano Aguzzi
Provider affiliationUniv.Hosp.Zurich/Inst.Neuropathology
Additional ownerDr. Andrew Steele, Whitehead Institute for Biomedical Research, Cambridge MA, USA
Genetic informationLarge deletion of Prnp and Prnd genes, termed Prn locus deletion.
Phenotypic informationMale mice are infertile.
Breeding historyBackcrossed to C57BL/6J for 7 generations.
References
  • Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.;Genoud Nicolas, Behrens Axel, Miele Gino, Robay Dimitri, Heppner Frank L, Freigang Stefan, Aguzzi Adriano, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;4198-203; 15007175

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • male infertility / MGI
  • nervous system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • immune system phenotype / MGI
  • teratozoospermia / MGI

Literature references

  • Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.;Genoud Nicolas, Behrens Axel, Miele Gino, Robay Dimitri, Heppner Frank L, Freigang Stefan, Aguzzi Adriano, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;4198-203; 15007175

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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