B6.129-Sfntm1.1Hher/Cnrm
| Status | Available to order |
| EMMA ID | EM:02444 |
| International strain name | B6.129-Sfntm1.1Hher/Cnrm |
| Alternative name | SFN conditional knock-out |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Sfntm1.1Hher, |
| Gene/Transgene symbol | Sfn |
Information from provider
| Provider | Heiko Hermeking |
| Provider affiliation | Molekulare Tumorpathologie, Institut für Pathologie |
| Additional owner | - |
| Genetic information | The targeting construct contains a wild-type Sfn allele plus a Neo-resistance marker, surrounded by frt sites, and the complete cassette is surrounded by LoxP sites. The internal Neo marker was removed by crossing to Flp-expressing mice, leaving a wild-type Sfn allele surrounded by LoxP sites. |
| Phenotypic information | When the floxed Sfn allele is removed homozygously, skin inflammation and hair loss in part of the mice; no abnormalities when the floxed allele is in place (also when homozygous). |
| Breeding history | Inbred. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |