CD1.129-Sp6tm1Ibmm/Cnrm
| Status | Available to order |
| EMMA ID | EM:02449 |
| International strain name | CD1.129-Sp6tm1Ibmm/Cnrm |
| Alternative name | Sp6.loxp-tm1Ibmm/CD1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Sp6tm1Ibmm, |
| Gene/Transgene symbol | Sp6 |
Information from provider
| Provider | Claude Szpirer |
| Provider affiliation | ULB-IBMM |
| Genetic information | The Sp6 gene was targeted by a replacement vector where the entire Sp6 gene was flanked by loxP sites (Sp6tm1Ibmm). In this strain, the gene is functional (no excision). This is the parental strain of the mutant where the Sp6 gene has been deleted (Sp6tm1.1Ibmm). |
| Phenotypic information | The mice are normal (the Sp6 protein is functional). |
| Breeding history | The modified allele was backcrossed for less than 10 generations (CD1) |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- The development of several organs and appendages is impaired in mice lacking Sp6.;Hertveldt Valérie, Louryan Stéphane, van Reeth Thierry, Drèze Pierre, van Vooren Pascale, Szpirer Josiane, Szpirer Claude, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;883-92; 18297738