C3HeB/FeJ-Dll1m1Mhda/Ieg

Status

Available to order

EMMA IDEM:02466
International strain nameC3HeB/FeJ-Dll1m1Mhda/Ieg
Alternative nameDll1_C413Y
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolDll1m1Mhda
Gene/Transgene symbolDll1

Information from provider

ProviderJohannes Beckers
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationA point mutation in exon 8 of the gene leads to a missense mutation from Cysteine to Tyrosine in the fourth EGF repeat of the Dll1 protein.
Phenotypic informationHomozygous animals show reduced viability, they are smaller, lighter and are in bad general condition. Only subtle skeletal alterations.
References
  • Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.;Rubio-Aliaga Isabel, Przemeck Gerhard K H, Fuchs Helmut, Gailus-Durner Valérie, Adler Thure, Hans Wolfgang, Horsch Marion, Rathkolb Birgit, Rozman Jan, Schrewe Anja, Wagner Sibylle, Hoelter Sabine M, Becker Lore, Klopstock Thomas, Wurst Wolfgang, Wolf Eckhard, Klingenspor Martin, Ivandic Boris T, Busch Dirk H, Beckers Johannes, Hrabé de Angelis Martin, ;2009;PloS one;4;e6054; 19562077
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C3HeB/FeJ

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased circulating triglyceride level / IMPC
  • abnormal behavior / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased grip strength / IMPC
IMPC phenotypes (gene matching)
  • increased monocyte cell number / IMPC
  • abnormal whole-body plethysmography / IMPC
  • decreased tidal volume / IMPC
  • abnormal behavior / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased body weight / IMPC
  • increased hemoglobin content / IMPC
  • decreased circulating calcium level / IMPC
  • decreased body temperature / IMPC
  • decreased circulating cholesterol level / IMPC
  • thrombocytopenia / IMPC
  • decreased circulating triglyceride level / IMPC
  • abnormal anxiety-related response / IMPC
  • decreased mean platelet volume / IMPC
  • decreased circulating glucose level / IMPC
  • decreased vertical activity / IMPC
  • increased leukocyte cell number / IMPC
  • decreased circulating potassium level / IMPC
  • hyperactivity / IMPC
  • decreased defecation amount / IMPC
  • decreased circulating sodium level / IMPC
  • increased lymphocyte cell number / IMPC
  • increased grip strength / IMPC
  • abnormal righting response / IMPC
  • decreased circulating chloride level / IMPC
  • increased granulocyte number / IMPC
  • abnormal eye electrophysiology / IMPC
MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • decreased body height / MGI
  • decreased body weight / MGI
  • hyperactivity / MGI
  • premature death / MGI
  • decreased circulating triglyceride level / MGI
  • increased lean body mass / MGI
  • increased mean systemic arterial blood pressure / MGI
  • decreased circulating cholesterol level / MGI
  • decreased heart rate / MGI
  • immune system phenotype / MGI
  • increased systemic arterial diastolic blood pressure / MGI
  • increased systemic arterial systolic blood pressure / MGI
  • increased blood uric acid level / MGI
  • increased basal metabolism / MGI
  • decreased total body fat amount / MGI
  • preweaning lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • decreased bone mineral density / MGI
  • abnormal vertebrae morphology / MGI
  • abnormal heart morphology / MGI
  • short tail / MGI
  • abnormal myogenesis / MGI
  • abnormal brain development / MGI
  • fused dorsal root ganglion / MGI
  • abnormal spinal nerve morphology / MGI
  • decreased body height / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • no spontaneous movement / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal somite development / MGI
  • incomplete somite formation / MGI
  • abnormal somite shape / MGI
  • decreased IgA level / MGI
  • hemorrhage / MGI
  • perinatal lethality / MGI
  • premature death / MGI
  • abnormal muscle morphology / MGI
  • abnormal axial skeleton morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased circulating triglyceride level / MGI
  • abnormal somatic nervous system morphology / MGI
  • situs inversus / MGI
  • abnormal notochord morphology / MGI
  • nervous system phenotype / MGI
  • abnormal defecation / MGI
  • abnormal pancreas development / MGI
  • increased lean body mass / MGI
  • decreased lean body mass / MGI
  • abnormal primitive node morphology / MGI
  • caudal body truncation / MGI
  • absent embryonic cilia / MGI
  • abnormal direction of embryo turning / MGI
  • abnormal direction of heart looping / MGI
  • decreased lumbar vertebrae number / MGI
  • decreased skeletal muscle mass / MGI
  • increased mean systemic arterial blood pressure / MGI
  • decreased B-1 B cell number / MGI
  • decreased neuronal precursor cell number / MGI
  • increased B cell number / MGI
  • decreased circulating cholesterol level / MGI
  • increased motor neuron number / MGI
  • decreased heart rate / MGI
  • muscle phenotype / MGI
  • embryo phenotype / MGI
  • immune system phenotype / MGI
  • decreased circulating total protein level / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • artery stenosis / MGI
  • increased systemic arterial diastolic blood pressure / MGI
  • increased systemic arterial systolic blood pressure / MGI
  • abnormal paraxial mesoderm morphology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased blood uric acid level / MGI
  • decreased blood uric acid level / MGI
  • increased neuron number / MGI
  • increased basal metabolism / MGI
  • abnormal neuron differentiation / MGI
  • decreased total body fat amount / MGI
  • abnormal bone mineral density / MGI
  • increased susceptibility to weight loss / MGI
  • aorta stenosis / MGI
  • abnormal Q wave / MGI
  • perinatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • decreased food intake / MGI
  • enlarged floor plate / MGI
  • abnormal somite border morphology / MGI
  • decreased basal metabolism / MGI

Literature references

  • Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.;Rubio-Aliaga Isabel, Przemeck Gerhard K H, Fuchs Helmut, Gailus-Durner Valérie, Adler Thure, Hans Wolfgang, Horsch Marion, Rathkolb Birgit, Rozman Jan, Schrewe Anja, Wagner Sibylle, Hoelter Sabine M, Becker Lore, Klopstock Thomas, Wurst Wolfgang, Wolf Eckhard, Klingenspor Martin, Ivandic Boris T, Busch Dirk H, Beckers Johannes, Hrabé de Angelis Martin, ;2009;PloS one;4;e6054; 19562077

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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