- abnormal cochlea morphology / MGI
- abnormal sensory neuron morphology / MGI
- abnormal sensory neuron innervation pattern / MGI
- abnormal geniculate ganglion morphology / MGI
- small nodose ganglion / MGI
- increased body weight / MGI
- impaired coordination / MGI
- impaired balance / MGI
- premature death / MGI
- abnormal innervation / MGI
- abnormal vestibular ganglion morphology / MGI
- abnormal crista ampullaris morphology / MGI
- vestibular ganglion degeneration / MGI
- hearing/vestibular/ear phenotype / MGI
- abnormal gustatory system morphology / MGI
- abnormal fungiform papillae morphology / MGI
B6;129P2-Bdnftm1(Ntf3)Pern/Kieg
Status | Available to order |
EMMA ID | EM:00247 |
International strain name | B6;129P2-Bdnftm1(Ntf3)Pern/Kieg |
Alternative name | BDNF(NT3/NT3) |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Bdnftm1(Ntf3)Pern, |
Gene/Transgene symbol | Bdnf |
Information from provider
Provider | Patrik Ernfors |
Provider affiliation | Department for Medical Biochemistry and Biophysics, Karolinska Institutet, MBB |
Genetic information | Exon 5 of the Bdnf gene was disrupted by an in-frame fusion of the Ntf3 (NT3) protein coding sequence and a floxed neo cassette. |
Phenotypic information | Homozygous mice die around postnatal day 27. They have defective coordination of balance and movement and lack nerve innervation of the inner ear caused by a loss of neurons in several sensory ganglia. |
References |
|
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development.;Agerman Karin, Hjerling-Leffler Jens, Blanchard Marie Pierre, Scarfone Eric, Canlon Barbara, Nosrat Christopher, Ernfors Patrik, ;2003;Development (Cambridge, England);130;1479-91; 12620975
- Differential influence of BDNF and NT3 on the expression of calcium binding proteins and neuropeptide Y in vivo.;Agerman Karin, Ernfors Patrik, ;2003;Neuroreport;14;2183-7; 14625444
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).