MGI phenotypes (allele matching)
B6;129P2-Bdkrb1tm1Bdr/Cnrm
| Status | Available to order |
| EMMA ID | EM:02482 |
| International strain name | B6;129P2-Bdkrb1tm1Bdr/Cnrm |
| Alternative name | B1 knockout |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Bdkrb1tm1Bdr, |
| Gene/Transgene symbol | Bdkrb1 |
Information from provider
| Provider | Thomas Walther |
| Provider affiliation | Hull York Medical School, University of Hull |
| Genetic information | The B1-receptor gene (Bdkrb1) was cloned from a genomic library of 129/SvJ mice in lambda FIXII. The targeting vector was generated by flanking the neomycin resistance gene with a 1.0 Kb genomic fragment 5' of the B1-coding region and a 7.0 Kb fragment 3' of the B1-coding region. |
| Phenotypic information | B1-deficient animals are grossly normal, fertile, and normotensive. |
| Breeding history | The line is currently backcrossed to a C57BL/6J background (second generation of backcrossing). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.;Pesquero J B, Araujo R C, Heppenstall P A, Stucky C L, Silva J A, Walther T, Oliveira S M, Pesquero J L, Paiva A C, Calixto J B, Lewin G R, Bader M, ;2000;Proceedings of the National Academy of Sciences of the United States of America;97;8140-5; 10859349