B6;129S7-Bdkrb2tm1Jfh/Cnrm

Status

Available to order

EMMA IDEM:02483
International strain nameB6;129S7-Bdkrb2tm1Jfh/Cnrm
Alternative nameB2 knockout
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolBdkrb2tm1Jfh,
Gene/Transgene symbolBdkrb2

Information from provider

ProviderJ. Fred Hess
Provider affiliationDepartment of Neuroscience Drug Discovery, Merck Research Laboratories
Genetic informationTargeting construct is derived from 129/SvEvJ DNA. The coding sequence of the B2 (Bdkrb2) receptor, which lies on a single exon (exon 4), was replaced by a PGKneo cassette.
Phenotypic informationAdult and juvenile B2 (Bdkrb2) knockout animals are indistinguishable from wild type littermates by visual inspection. No abnormalities were seen in either the gross pathology or the histopathology.
Breeding historyThe animals were backcrossed on a C57BL/6J background.
References
  • Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons.;Borkowski J A, Ransom R W, Seabrook G R, Trumbauer M, Chen H, Hill R G, Strader C D, Hess J F, ;1995;The Journal of biological chemistry;270;13706-10; 7775424
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • abnormal kidney cortex morphology / MGI
  • kidney cortex cysts / MGI
  • abnormal kidney development / MGI
  • premature death / MGI
  • abnormal kidney morphology / MGI
  • abnormal kidney physiology / MGI
  • abnormal renal tubule morphology / MGI
  • dilated renal tubules / MGI
  • abnormal Leydig cell morphology / MGI
  • abnormal juxtaglomerular apparatus morphology / MGI
  • abnormal nephron morphology / MGI
  • abnormal proximal convoluted tubule morphology / MGI
  • abnormal renal glomerulus morphology / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • cardiovascular system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • increased circulating creatinine level / MGI
  • increased blood urea nitrogen level / MGI
  • decreased blood urea nitrogen level / MGI
  • abnormal renal tubule epithelium morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • abnormal juxtaglomerular cell morphology / MGI
  • abnormal glomerular capillary morphology / MGI
  • abnormal kidney medullary ray morphology / MGI
  • increased glomerular capsule space / MGI
  • abnormal mitochondrial chromosome morphology / MGI
  • decreased urine nitrite level / MGI

Literature references

  • Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons.;Borkowski J A, Ransom R W, Seabrook G R, Trumbauer M, Chen H, Hill R G, Strader C D, Hess J F, ;1995;The Journal of biological chemistry;270;13706-10; 7775424

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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