NMRI-Tg(Agt)123Uhg/Cnrm
| Status | Available to order |
| EMMA ID | EM:02484 |
| International strain name | NMRI-Tg(Agt)123Uhg/Cnrm |
| Alternative name | TGM(rAOGEN)102 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Agt)123Uhg, |
| Gene/Transgene symbol | Tg(Agt)123Uhg |
Information from provider
| Provider | Thomas Walther |
| Provider affiliation | Hull York Medical School, University of Hull |
| Genetic information | A genomic rat AOGEN (Agt) clone (pRag15U), including 1.6 kb of 5' flanking sequences, was microinjected into fertilized eggs of NMRI mice as a 14.2 kb linear EcoRI-Hindlll fragment. |
| Phenotypic information | Transgenic mice have elevated plasma levels of angiotensinogen and angiotensin II and have therefore an increased mean arterial pressure. |
| Breeding history | Animals were not backcrossed and are maintained on a NMRI background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- High blood pressure in transgenic mice carrying the rat angiotensinogen gene.;Kimura S, Mullins J J, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob H, Fuxe K, Ganten D, Kaling M, ;1992;The EMBO journal;11;821-7; 1547785