MGI phenotypes (allele matching)
B6;129P2-Dbptm1Schb/Cnrm
| Status | Available to order |
| EMMA ID | EM:02485 |
| International strain name | B6;129P2-Dbptm1Schb/Cnrm |
| Alternative name | DBP-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Dbptm1Schb, |
| Gene/Transgene symbol | Dbp |
Information from provider
| Provider | Ueli Schibler |
| Provider affiliation | University of Geneva |
| Genetic information | A LacZ-neo cassette has been inserted between the BstEII site of exon1 and the end of the exon4, disrupting the entire coding sequence by homologous recombination. |
| Phenotypic information | The mice have a shorter circadian period and display less locomotor activity than wild-type. |
| Breeding history | No backcross but crossed with inbred C57BL/6 mice and then intercrossed. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Perrault syndrome / Orphanet_2855
- Bifunctional enzyme deficiency / Orphanet_300
Literature references
- The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior.;Lopez-Molina L, Conquet F, Dubois-Dauphin M, Schibler U, ;1997;The EMBO journal;16;6762-71; 9362490