MGI phenotypes (allele matching)
B6;129S2-Teftm1Schb/Cnrm
| Status | Available to order |
| EMMA ID | EM:02486 |
| International strain name | B6;129S2-Teftm1Schb/Cnrm |
| Alternative name | TEF-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Teftm1Schb, |
| Gene/Transgene symbol | Tef |
Information from provider
| Provider | Ueli Schibler |
| Provider affiliation | University of Geneva |
| Genetic information | Targeting construct is derived from 129 DNA. A lacZ and PGK-neo replaced exon 2, which encodes the transactivation domain. Western blot indicated absence of protein in the liver of mutants. |
| Phenotypic information | Homozygotes Teftm1Schb/Teftm1Schb have spontaneous seizures but less frequent than triple knockout mice (Dbptm1Schb/tm1Schb; Hlftm1Schb/tm1Schb; Teftm1Schb/tm1Schb), spontaneous high-voltage and absence-like seizures, no generalized tonic-clonic epilepsies. |
| Breeding history | No backcross but crossed with inbred C57BL/6 mice and then intercrossed. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- The loss of circadian PAR bZip transcription factors results in epilepsy.;Gachon Frédéric, Fonjallaz Philippe, Damiola Francesca, Gos Pascal, Kodama Tohru, Zakany Jozsef, Duboule Denis, Petit Brice, Tafti Mehdi, Schibler Ueli, ;2004;Genes & development;18;1397-412; 15175240