| Status | Available to order |
| EMMA ID | EM:02487 |
| International strain name | B6.129S2-Nr1d1tm1Schb/Cnrm |
| Alternative name | REV-ERBalpha-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nr1d1tm1Schb, |
| Gene/Transgene symbol | Nr1d1 |
| Provider | Ueli Schibler |
| Provider affiliation | University of Geneva |
| Genetic information | A genomic fragment containing part of exon 2, exons 3 and 4 and part of exon 5 was replaced with an in-frame lacZ gene and a neomycin selection cassette. Northern blot analysis demonstrated that no detectable transcript is expressed from this allele, and Western blot analysis confirmed that no detectable protein is made from this allele. |
| Phenotypic information | Homozygotes for targeted null mutations exhibit altered circadian behavior and mild alterations in cytoarchitecture of the cerebellum. Litter size is reduced by half in mutant females. |
| Breeding history | Backcrossed to C57BL/6J background for more than 6 generations. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
