STOCK Grm7Tg(SMN2)89Ahmb Smg6Tg(SMN1*delta5)1Pks Smn1tm1Msd/H

Status

Available to order

EMMA IDEM:02500
Citation informationRRID:IMSR_EM:02500 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Grm7Tg(SMN2)89Ahmb Smg6Tg(SMN1*delta5)1Pks Smn1tm1Msd/H
Alternative nameSMN Delta 5 /SMN2 low
Strain typeTransgenic Strains
Allele/Transgene symbolSmg6Tg(SMN1*delta5)1Pks, Smn1tm1Msd, Grm7Tg(SMN2)89Ahmb
Gene/Transgene symbolSmg6, Smn1, Grm7

Information from provider

ProviderNicholas Parkinson
Provider affiliationUniversity of Oxford
Genetic informationThis strain represents the SMN-Delta 5 transgene (EMMA strain EM:02416) bred, as a heterozygote, onto the SMN2-low line (see Monani et al., Hum Mol Genet 9 3 2000) which contains a knockout allele of the endogenous Smn locus and is homozygous for the human SMN2 BAC transgenic.
Phenotypic informationRescues post-natal lethality of SMN2-low strain.
Breeding historyAnimals heterozygous for the SMN-Delta 5 transgene were bred onto the SMN2-low line.
References
  • The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy.;Monani U R, Sendtner M, Coovert D D, Parsons D W, Andreassi C, Le T T, Jablonka S, Schrank B, Rossoll W, Prior T W, Morris G E, Burghes A H, ;2000;Human molecular genetics;9;333-9; 10655541
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • impaired righting response / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal skin morphology / IMPC
  • limb grasping / IMPC
  • scaly skin / IMPC
  • abnormal spleen morphology / IMPC
  • enlarged spleen / IMPC
  • decreased hematocrit / IMPC
  • increased mean platelet volume / IMPC
  • abnormal startle reflex / IMPC
  • embryonic lethality prior to organogenesis / IMPC
  • decreased anxiety-related response / IMPC
  • increased grip strength / IMPC
MGI phenotypes (allele matching)
  • embryonic lethality / MGI
  • hypoactivity / MGI
  • decreased vertical activity / MGI
  • nervous system phenotype / MGI
  • decreased grip strength / MGI
  • abnormal apoptosis / MGI
  • abnormal embryonic tissue morphology / MGI
  • absent blastocoele / MGI
  • embryonic growth retardation / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • decreased motor neuron number / MGI
  • decreased body size / MGI
  • abnormal gait / MGI
  • premature death / MGI
  • abnormal spine curvature / MGI
  • paraparesis / MGI
MGI phenotypes (gene matching)
  • convulsive seizures / MGI
  • impaired coordination / MGI
  • abnormal contextual conditioning behavior / MGI
  • seizures / MGI
  • hyperresponsive to tactile stimuli / MGI
  • abnormal conditioned taste aversion behavior / MGI
  • increased susceptibility to pharmacologically induced seizures / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • nervous system phenotype / MGI
  • abnormal spatial working memory / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • no abnormal phenotype detected / MGI
  • embryonic growth retardation / MGI
  • embryonic lethality / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality at implantation, incomplete penetrance / MGI
  • decreased inner cell mass proliferation / MGI
  • decreased bone mineral density / MGI
  • distended pericardium / MGI
  • decreased motor neuron number / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • epidermal necrosis / MGI
  • decreased body size / MGI
  • hypoactivity / MGI
  • abnormal gait / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal apoptosis / MGI
  • embryonic growth arrest / MGI
  • premature death / MGI
  • abnormal embryonic tissue morphology / MGI
  • no abnormal phenotype detected / MGI
  • absent blastocoele / MGI
  • hyperresponsive to tactile stimuli / MGI
  • decreased vertical activity / MGI
  • abnormal endplate potential / MGI
  • no phenotypic analysis / MGI
  • nervous system phenotype / MGI
  • abnormal synaptic transmission / MGI
  • enhanced coordination / MGI
  • embryonic growth retardation / MGI
  • decreased thermal nociceptive threshold / MGI
  • abnormal spine curvature / MGI
  • abnormal miniature endplate potential / MGI
  • decreased heart rate / MGI
  • hyperalgesia / MGI
  • increased skeletal muscle fiber size / MGI
  • decreased skeletal muscle fiber size / MGI
  • paraparesis / MGI
  • decreased grip strength / MGI
  • decreased bone mineral content / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • tail necrosis / MGI

Literature references

  • The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy.;Monani U R, Sendtner M, Coovert D D, Parsons D W, Andreassi C, Le T T, Jablonka S, Schrank B, Rossoll W, Prior T W, Morris G E, Burghes A H, ;2000;Human molecular genetics;9;333-9; 10655541

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
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