MGI phenotypes (allele matching)
B6;129P2-Prndtm1Aag/Cnrm
| Status | Available to order |
| EMMA ID | EM:02571 |
| International strain name | B6;129P2-Prndtm1Aag/Cnrm |
| Alternative name | B6,129-Prnd-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prndtm1Aag, |
| Gene/Transgene symbol | Prnd |
Information from provider
| Provider | Adriano Aguzzi |
| Provider affiliation | Univ.Hosp.Zurich/Inst.Neuropathology |
| Additional owner | Dr. Andrew Steele, Whitehead Institute for Biomedical Research, Cambridge MA, USA |
| Genetic information | Knock-out of the Prnd gene, a double (German "doppel", Dpl) of the Prnp gene. The complete Prnd open reading frame is replaced with a neomycin resistance gene. |
| Phenotypic information | Homozygous males are infertile. Spermatids of Dpl mutants are reduced in numbers, immobile, malformed and unable to fertilize oocytes in vitro. |
| Breeding history | Prnd+/- males were backcrossed several times to C57BL/6 females. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Absence of the prion protein homologue Doppel causes male sterility.;Behrens Axel, Genoud Nicolas, Naumann Heike, Rülicke Thomas, Janett Fredi, Heppner Frank L, Ledermann Birgit, Aguzzi Adriano, ;2002;The EMBO journal;21;3652-8; 12110578
- Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.;Genoud Nicolas, Behrens Axel, Miele Gino, Robay Dimitri, Heppner Frank L, Freigang Stefan, Aguzzi Adriano, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;4198-203; 15007175
- Prion proteins and infertility: insight from mouse models.;Genoud N, Behrens A, Arrighi I, Aguzzi A, ;2003;Cytogenetic and genome research;103;285-9; 15051949
- Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel.;Behrens A, Brandner S, Genoud N, Aguzzi A, ;2001;EMBO reports;2;347-52; 11306558