B6N.129-Artm1Verh/Cnrm
| Status | Available to order |
| EMMA ID | EM:02579 |
| International strain name | B6N.129-Artm1Verh/Cnrm |
| Alternative name | ARflox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Artm1Verh, |
| Gene/Transgene symbol | Ar |
Information from provider
| Provider | Guido Verhoeven |
| Provider affiliation | LEGENDO, Catholic University Leuven |
| Genetic information | Mice carry an androgen receptor (Ar) gene on their X chromosome in which exon 2 is flanked by loxP-sites (floxed), allowing the generation of conditional (cell-specific) knockout of the Ar gene. |
| Phenotypic information | ARflox mice do not exhibit any phenotype. |
| Breeding history | Mice were backcrossed for over 12 generations with C57BL/6N mice. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.;De Gendt Karel, Swinnen Johannes V, Saunders Philippa T K, Schoonjans Luc, Dewerchin Mieke, Devos Ann, Tan Karen, Atanassova Nina, Claessens Frank, Lécureuil Charlotte, Heyns Walter, Carmeliet Peter, Guillou Florian, Sharpe Richard M, Verhoeven Guido, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;1327-32; 14745012